Understanding Ketamine Treatment for Depression

As awareness of mental health grows and new treatment options emerge, ketamine therapy has gained significant attention for its potential in treating depression. Once used exclusively as an anesthetic, ketamine is now being explored for its rapid antidepressant effects — offering new hope for individuals who have not found relief with traditional medications.

This article explores the science behind ketamine, its evolution as a treatment, what to expect during therapy, its effectiveness, and potential side effects — helping you better understand whether ketamine may be right for you.

The Science Behind Ketamine

How Ketamine Works
When administered, ketamine modulates glutamate, the brain’s main excitatory neurotransmitter. By blocking NMDA receptors, it triggers a surge of glutamate, enhancing brain connectivity and potentially reversing depression’s effects.

Ketamine also increases levels of BDNF (brain-derived neurotrophic factor) — a protein vital for neuron growth and repair. Higher BDNF supports mood, cognition, and neuroplasticity, allowing the brain to form new pathways critical for recovery.

Rapid Neurotransmission Effects
Unlike conventional antidepressants that may take weeks, ketamine often provides relief within hours. This rapid response is especially valuable for those with treatment-resistant depression or suicidal thoughts. Research also suggests benefits for PTSD and anxiety, with ketamine’s dissociative effects helping patients process traumatic memories in new ways.

The Evolution of Ketamine as a Treatment

Introduced in the 1960s as an anesthetic, ketamine’s mood-enhancing effects soon caught clinical attention. Over the last decade, studies have documented significant improvements in depressive symptoms, positioning ketamine as a promising alternative for patients unresponsive to standard therapies.

Although not FDA-approved specifically for depression, ketamine is commonly used off-label in clinics like Ketavita, where it’s administered safely under professional care. Delivery methods include intravenous infusions, intranasal sprays, or intramuscular injections.

The Treatment Process at Ketavita

• Comprehensive Consultation: A psychiatric and medical evaluation ensures ketamine is safe and appropriate.

• Personalized Plan: Dosages and frequency are tailored to each patient’s condition and goals.

• Infusion Sessions: IV infusions typically last 40–60 minutes, with patients monitored closely throughout.

• Post-Treatment Care: Patients are observed before discharge and supported with ongoing follow-up visits.

Patients often describe temporary dissociation or dreamlike sensations, which fade shortly after treatment. Many notice improved mood, energy, and clarity soon afterward.

Effectiveness and Success Rates

Research shows that about 70% of patients with treatment-resistant depression respond positively to ketamine, often experiencing symptom relief shortly after the first few sessions. For lasting improvement, booster infusions or integration with psychotherapy may be recommended.

This combination not only maximizes ketamine’s benefits but also helps patients build long-term coping strategies.

Potential Side Effects and Risks

Short-Term Effects: Dizziness, nausea, or mild dissociation, which typically subside quickly.
Long-Term Considerations: While ongoing research continues, potential risks of dependency or cognitive issues highlight the need for professional monitoring and comprehensive treatment plans.

At Ketavita, patient safety is our top priority. Every infusion is supervised by highly trained providers in a calm, supportive environment.

Is Ketamine Therapy Right for You?

Living with depression doesn’t mean your options are limited. At Ketavita in Green Bay, WI, we specialize in ketamine therapy — a proven treatment offering fast, effective relief for patients who have struggled with traditional antidepressants.

Take the first step toward feeling like yourself again. Contact Ketavita today to schedule your consultation and explore whether ketamine therapy can help you reclaim your mental health.